abstract：:Considerations are given to special features of the nuclear envelope that might occasion segmental exchange between sister chromatids. The underlying dynamics may lead to illegal apposition of originally distant sequences and/or to modulations in the topologic orientation of genes on chromatid segments involved in suc...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：1991-12-01 00:00:00

abstract：:This hypothesized reflex relates the vertical direction of gaze to the amount of tension exerted by the ciliary muscle. Based on simple observations the following is assumed. When looking downwards a tendency for closer focusing (near searching) exists even without a specific visual stimulus, whereas looking up favors...

journal_title：Medical hypotheses

authors： Blumenthal EZ

更新日期：1991-12-01 00:00:00

abstract：:In a recent issue of Medical Hypotheses, Dr H L Newbold repeats the assertion that the cause of James B Duke's death in 1925 was pernicious anemia. Dr Newbold postulates that Mr Duke was neurologically impaired as a result of vitamin B-12 deficiency and that he suffered from depression. In an attempt to relieve this d...

journal_title：Medical hypotheses

authors： Halperin EC

更新日期：1991-11-01 00:00:00

abstract：:Trypanosomiasis (whether African sleeping sickness, or American Chaga's disease) is caused by an infection with a protozoan parasite, i.e. the trypanosome. This carries fatal sequences in the untreated host. Currently available chemotherapeutic drugs (some of which cure by involving reactive oxygen species (ROS] are n...

journal_title：Medical hypotheses

authors： Eze MO

更新日期：1991-11-01 00:00:00

abstract：:Homeostasis, or the maintenance of constant internal environment in the organism, is disrupted by injury. In this case, pathological defence reactions such as inflammation and healing take place in order to restore it. They succeed if etiological harmful factors are eliminated. In the opposite case, constant injury le...

journal_title：Medical hypotheses

authors： Beranek JT

更新日期：1991-10-01 00:00:00

abstract：:In a previous paper, I have proposed that the deficiency of an endogenous caffeine-like substance is the underlying pathogenic mechanism in schizophrenia (1). In the present paper, my new concept is used to explain many of the clinical, biochemical, radiologic and pharmacologic facts about schizophrenia. ...

journal_title：Medical hypotheses

authors： Missak SS

更新日期：1991-10-01 00:00:00

abstract：:Regulation of ion transport across the airway mucosa may be involved in the mechanisms producing hyperreactivity and asthma. Atrial Natriuretic Peptide (ANP) has been proposed to participate in the pathogenesis of asthma, and it has been found to have a bronchodilatory effect on asthmatic patients. Experimental eviden...

journal_title：Medical hypotheses

authors： Almirall JJ,Hedenstierna G

更新日期：1991-09-01 00:00:00

abstract：:Immunology has many effects on atherogenesis. In addition to their usual action risk factors for atherosclerosis have an immunomodulating effect and immunomodulation may be a new treatment of atherosclerosis. ...

journal_title：Medical hypotheses

authors： Clerc G

更新日期：1991-09-01 00:00:00

abstract：:The favourable effects of eicosapentaenoic acid (EPA)- and doco-sahexaenoic acid (DHA)-rich diets (marine fish, fish oil) on several risk factors for cardiovascular disease are well established. The present survey describes possible new indications for diets supplemented with long-chain n-3 fatty acids. During a stand...

journal_title：Medical hypotheses

authors： Singer P,Richter-Heinrich E

更新日期：1991-09-01 00:00:00

abstract：:CML, a myeloproliferative clonal disorder of myeloid stem cells, is characterized by the consistent presence of a bcr-c-abl fusion gene which is formed as a result of a translocation of the c-abl gene from chromosome 9 to downstream of the bcr gene on chromosome 22 (ph'). Current approaches to the treatment of CML are...

journal_title：Medical hypotheses

authors： Nadkarni KS,Datar RH,Rao SG

更新日期：1991-08-01 00:00:00

abstract：:The etiology of Insulin Dependent Diabetes Mellitus (IDDM) is reviewed and discussed using Rothman's deterministic model for causal inference. Intercontinental comparisons, familial aggregation, seasonal variation, maternal age, breast-feeding and infectious agents are reviewed within the context of IDDM causation. Ge...

journal_title：Medical hypotheses

authors： Sumburèru D

更新日期：1991-08-01 00:00:00

abstract：:In this work some aspects of carcinogenesis are given. The importance of the emergence of Z or H DNA structure in the gene, or in the flanking gene sequences for the gene deletion and unusual gene recombination, is discussed. Some considerations on the role of selective pressure (of polyamines, of Mg2+, of the various...

journal_title：Medical hypotheses

authors： Juranic Z,Kidric M,Tomin R,Juranić I,Spuzić I,Petrović J

更新日期：1991-08-01 00:00:00

abstract：:It is proposed here that the initial events in gastric carcinogenesis occur at the junction of the oxyntic and antral mucosae. Intestinal metaplasia represents an adaptive counter-response to early neoplastic change at this site. Chronic gastric ulceration may arise due to the elimination of overtly dedifferentiated c...

journal_title：Medical hypotheses

authors： Seery JP

更新日期：1991-07-01 00:00:00

abstract：:The initial treatment for hypotension due to blood loss is intravenous fluids. Occasionally there is need for additional medication, as well as stopping the source of the bleeding. The literature in the main discusses the use of dopamine. Ephedrine has not been reviewed as useful in such situations. This article discu...

journal_title：Medical hypotheses

authors： Eldor J

更新日期：1991-07-01 00:00:00

abstract：:The 'Big Bang' is used to describe the origin of the Universe. While such an event could not create itself the expression is graphic. Tissue damage, traumatic, thermal, chemical; bites; insect, animal or human are all bad, but also well known factors which favor and initiate pathogenic activity. Antedating and outrank...

journal_title：Medical hypotheses

authors： Baggot MG

更新日期：1991-06-01 00:00:00

abstract：:Trypanosoma cruzi is thought to selectively destroy the postganglionic cardiac vagal neurons of chagasic cardiac patients. This theory is based on morphologic and functional evidences obtained from chagasic individuals who were in very advanced stages of the disease. We have studied chagasic patients who were in both ...

journal_title：Medical hypotheses

authors： Davila DF,Donis JH,Torres A,Gottberg CF,Rossell O

更新日期：1991-06-01 00:00:00

abstract：:The assumption is introduced that there are two types of adaptive responses in central neurons in response to significantly changed circuit activity. Morphological synaptic modifications and synapse turnover are thought to be involved in both of these responses, in such a way that in the first case they are to restore...

journal_title：Medical hypotheses

authors： Benusková L

更新日期：1991-05-01 00:00:00

abstract：:The epidemiologic findings of Kaposi's sarcoma (KS) among patients with the acquired immunodeficiency syndrome (AIDS) suggest that human immunodeficiency virus (HIV) infection is insufficient for the development of KS. It was speculated that another sexually transmitted infection is responsible for the markedly increa...

journal_title：Medical hypotheses

authors： Rechavi G,Katzir N,Ramot B

更新日期：1991-04-01 00:00:00

abstract：:Many embryonic genes may be sets of repeated genes. Processes of differentiation where the quantity of gene activity changes during embryogenesis may not reflect the transcription rate per se but instead be a result of the state of expression of constitutive repeated genes. Such repeated genes (in fact or theory) is d...

journal_title：Medical hypotheses

authors： Hancock RL

更新日期：1991-03-01 00:00:00

abstract：:Alcoholism is a major and world-wide health problem. A characteristic pattern of congenital defects, known as the fetal alcohol syndrome, has been detected in the offspring of mothers who are chronic alcoholics. The mechanism underlying the teratogenic effects of ethanol is not known. An important hypothesis is that e...

journal_title：Medical hypotheses

authors： Seyoum GG,Persaud TV

更新日期：1991-02-01 00:00:00

abstract：:A major factor relating to the oversight of neurological dysfunction and seizures caused by magnesium (Mg++) depletion, involves the buffer functions of the skeletal system orchestrated primarily by the parathyroid. A Mg++ depleted subject may appear relatively asymptomatic until a short period after homeostatic respo...

journal_title：Medical hypotheses

authors： Langley WF,Mann DJ

更新日期：1991-01-01 00:00:00

abstract：:Narcolepsy is a disorder characterized by the sudden urge to sleep. The biochemical etiology of this disorder is believed to be due to dopamine abnormalities. Since the precursor of dopamine is L-tyrosine, the administration of this amino acid may prove beneficial in the treatment of narcolepsy. Preliminary research a...

journal_title：Medical hypotheses

authors： Roufs JB

更新日期：1990-12-01 00:00:00

abstract：:Although the role of the lymphatic circulation in the uptake of dietary fat is well established, the absorption of water-soluble compounds, secreted by the enterocyte into the lymph, has received little attention. In the present study an estimate is made of the amount of dietary glucose that can be absorbed via the ly...

journal_title：Medical hypotheses

authors： Argilés JM,Fernández-López JA,Casado J,Alemany M

更新日期：1990-11-01 00:00:00

abstract：:Electron spin resonance (ESR) spin trapping methodology has been used to study the reactions of manganese dusts with glutathione, employing alpha-(4-pyridyl-1-oxide)-N-tert-butyl-nitrone (PBN) and 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as spin traps. The results show evidence for the glutathionyl radical formation in...

journal_title：Medical hypotheses

authors： Shi XL,Dalal NS

更新日期：1990-10-01 00:00:00

abstract：:The AIDS dementia complex and peripheral neuropathy in AIDS are considered to be direct or indirect manifestations of HIV infection, yet the pathogenesis in unclear. There are parallels between AIDS and Tangier disease clinically and histopathologically and in lipid metabolism. The neurological disorders in AIDS may b...

journal_title：Medical hypotheses

authors： Falkenbach A,Klauke S,Althoff PH

更新日期：1990-09-01 00:00:00

abstract：:Anorexia nervosa was explored as the possible expression of an aberration of the processing of information which ordinarily has value in life protection or extension. Each of 6 areas was briefly reviewed, and noted to have the potential for failure to balance 2 or more factors. Anorexia nervosa may prove to be a psych...

journal_title：Medical hypotheses

authors： Spencer RP

更新日期：1990-09-01 00:00:00

abstract：:Space adaptation syndrome (SAS) incapacitates about 50% of the astronauts with symptoms of headache, malaise, vomiting, vertigo, etc. A hypothesis that SAS is caused by elevated intracranial pressure secondary to the cephalad fluid shift in zero G is proposed. A mechanism of how the cephalad fluid shift could cause el...

journal_title：Medical hypotheses

authors： Jennings T

更新日期：1990-08-01 00:00:00

abstract：:Some genes such as those for histones and RNAs are conserved unchanged through much of evolution and have numerous tandem repeat copies in the genome. It is proposed that as yet undetected 'polystrand' enzymes use such multiple copies as a means of conserving their sequence by comparing the copies and eliminating erro...

journal_title：Medical hypotheses

authors： Frei JV

更新日期：1990-08-01 00:00:00

abstract：:The morphological changes used to confirm a diagnosis of coeliac disease (CD) are precisely those predicted if the surface energy of the interface between duodenal epithelium and the luminal contents were raised to levels comparable to those demonstrated by the hydrophobic nature of the stomach wall. This hypothesis p...

journal_title：Medical hypotheses

authors： Hills BA,Godwin IR

更新日期：1990-07-01 00:00:00

abstract：:This article proposes the hypothesis that allantois is the anatomical homologue of bursa of Fabricius in mammalia. This hypothesis is based on immunohistochemical study of sections from hematopoietic organs of three fetuses with cloacal exstrophy. In the complex maldevelopment of cloacal exstrophy the common features ...

journal_title：Medical hypotheses

authors： Zarabi CM

更新日期：1990-06-01 00:00:00

abstract：:Several earlier observations by us and other investigators led us to propose a thesis that B lymphocytes, when activated by a virus, allo-antigen or bacterial protein would enter into effector arm of the immune response and cause allograft and tumor rejection or GVH-type of lesion in immunosuppressed animals. These ef...

journal_title：Medical hypotheses

authors： Krishnan G

更新日期：1990-05-01 00:00:00

abstract：:Logic, a fundamental component of research in the exact sciences is often not applied in prominent fields of medical research. Investigation into the aetiopathogenesis of headache, vertigo, and fatigue--acknowledged as the commonest and amongst the most prominent and debilitating of symptoms known to mankind--may be s...

journal_title：Medical hypotheses

authors： Eidelman D

更新日期：1990-04-01 00:00:00

abstract：:Recent work by molecular biologists into the behaviour of progesterone receptors (PR) has suggested an aetiological hypothesis for premenstrual syndrome (PMS). The proposition is that PMS is related to the transport by PR of sufficient progesterone (P) molecules into the cell nuclei during menstruating years. PR are w...

journal_title：Medical hypotheses

authors： Dalton K

更新日期：1990-04-01 00:00:00

abstract：:About 19-26% of patients with chronic lymphocytic leukemia (CLL) have intractable disease resistant to chemotherapy, have a relatively short median survival time and are responsive to splenectomy. Lymphocytes from patients with intractable CLL are resistant in vitro to X-irradiation and to colchicine. Responsive CLL i...

journal_title：Medical hypotheses

authors： Schrek R

更新日期：1990-02-01 00:00:00

abstract：:Ontogenesis might be considered as the development of phylogenetically consequent genic systems that mainly imply: homoeotic genes and ras protooncogene in segmentation; ras and myc protooncogenes in gastrulation; ras, myc and other nuclear protooncogenes in organogenesis; ras myc, other nuclear and cytomembrane proto...

journal_title：Medical hypotheses

authors： Manzo G

更新日期：1989-12-01 00:00:00

abstract：:We propose that in any acid-base disturbance there is a predictable mathematical relationship between the changes in the individual serum anionic concentrations of chloride, bicarbonate and the unmeasured anion gap. Two indices were developed, from the ratios of the changes in these anionic concentrations, that are us...

journal_title：Medical hypotheses

authors： Lee SM

更新日期：1989-11-01 00:00:00

abstract：:Auer rods are cytoplasmic inclusions found only in the leukaemic cells of some cases of acute myeloid leukaemia (AML). The ultrastructure of Auer rods is different in different sub-types of the disease and it is suggested here that this may be a consequence of the Auer rods consisting of different crystalline forms of...

journal_title：Medical hypotheses

authors： Pearson EC

更新日期：1989-11-01 00:00:00

abstract：:Sperm production is regulated by inhibin. Inhibin secretion may be controlled by the number of ejaculations. The more the number of ejaculations, the less the inhibin in blood and the more the production of spermatozoa. ...

journal_title：Medical hypotheses

authors： Skandhan KP

更新日期：1989-10-01 00:00:00

abstract：:We develop here the hypothesis that polycystic kidneys (PCK) may maintain, to a certain extent, the ability to perform endocrine functions. We know that patients with adult polycystic kidney disease (APCKD) produce more erythropoietin and maintain a higher hematocrit than patients with other primary diseases of the ki...

journal_title：Medical hypotheses

authors： Rotellar C,Gelfand MC

更新日期：1989-09-01 00:00:00

abstract：:Exercise is thought to have considerable potential as a preventive for osteoporosis. We critically examined 27 studies that address the prophylactic role of exercise in osteoporosis. The results from both cross-sectional and longitudinal studies showed that differences in bone mass were more pronounced in the axial sk...

journal_title：Medical hypotheses

authors： Block JE,Smith R,Friedlander A,Genant HK

更新日期：1989-09-01 00:00:00